Sequence Landmark Patterns Identify and Characterize Protein Families
نویسندگان
چکیده
منابع مشابه
FixingTIM: interactive exploration of sequence and structural data to identify functional mutations in protein families
BACKGROUND Knowledge of the 3D structure and functionality of proteins can lead to insight into the associated cellular processes, speed up the creation of pharmaceutical products, and develop drugs that are more effective in combating disease. METHODS We present the design and implementation of a visual mining and analysis tool to help identify protein mutations across a family of structural...
متن کاملCharacterization of protein families, sequence patterns, and functional annotations in large data sets
Bioinformatics involves storing, analyzing and making predictions on massive amounts of protein and nucleotide sequence data. The thesis consists of six papers and is focused on proteins. It describes the utilization of bioinformatics techniques to characterize protein families and to detect patterns in gene expression and in polypeptide occurrences. Two protein families were bioinformatically ...
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In protein structure space, protein structures cluster into four elongated regions when mapped based solely on similarity among the 3D structures. These four regions correspond to the four major classes of present-day proteins defined by the contents of secondary structure types and their topological arrangement. Evolution of and restriction to these four classes suggest that, in most cases, th...
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MOTIVATION Most proteins have evolved to perform specific functions that are dependent on the adoption of well-defined three-dimensional (3D) structures. Specific patterns of conserved residues in amino acid sequences of divergently evolved proteins are frequently observed; these may reflect evolutionary restraints arising both from the need to maintain tertiary structure and the requirement to...
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F O R I N T E G R A T I V E B I O I N F O R M A T I C S V U E .....acctc ctgtgcaag acatgaaaca cccgatttac nctgtggttc cccagatgg gtcctgtccc aggtgcacct gcaggagtcg gcccaggac tggggaagcc tccagagctc aaaaccccac tggtgacac aactcacaca tgcccacggt gcccagagcc aaatcttgt gacacacctc ccccgtgccc acggtgccca agcccaaat cttgtgacac acctccccca tgcccacggt cccagagcc caaatcttgt gacacacctc ccccgtgccc cggtgccca gcacctgaac tc...
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ژورنال
عنوان ژورنال: Structure
سال: 2002
ISSN: 0969-2126
DOI: 10.1016/s0969-2126(02)00854-7